Home > Browse Issues > Vol.30 No.6
Focal Adhesion Kinase and Cell Migration
Jun-Yan An, Xiao-Lan Zhang*
Hebei Province Key Laboratory, Hebei Institute of Digestive Disease, the Second Hospital of
Abstract: The process of cell migration is initiated by protrusion at the leading edge of the cell， the formation of peripheral adhesions， the exertion of force on these adhesions， and finally the release of the adhesions at the rear of the cell. Focal adhesion kinase is intimately involved in the regulation of this process through its kinase activity and its function as a scaffolding molecule. This review focus is limited to the signal transduction pathways mediated by focal adhesion kinase and its role in regulation of cell migration.
CN
EN