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SUMOylation Regulating NF-κB Signaling Pathway
Yang Gao, Si-Jiao Chen*, Jin-Dan Song1
Teaching and Research Office for Geriatric Disease of the First Affiliated Hospital of China Medical University,Shenyang 110001, China; 1Key Laboratory of Cell Biology of Ministry of Health, Medical Molecular Biology Research Institute, China M
Abstract: We intitule the progress that the small ubiquitin-related modifier (SUMO) covalently attaches to lysine residues of target proteins， through a series of SUMO enzymes-mediated biochemical cascades， to stabilize them from degradation as SUMOylation. Nuclear factor κB (NF-κB) has been well known as a regulator participating in inflammation and immunity reactions， and it also gets close related to the source and development of diabetes. According to the investigation these years， not only SUMOylation of the inhibitor of NF-κB (IκB) takes participate in the regulation of NF-κB signaling pathway， but also the SUMO enzymes can directly regulate transcriptions of the NF-κB target genes. Now we will summarize as below: the current investigation about the subtype and structure of SUMO， the processes of SUMOylation and desumoylation， the regulations of SUMO and its enzymes on NF-κB signaling pathway and their correlations with diabetes.
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