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The Relationship between Mesenchymal Stem Cells and Tumor
Zhen-Yu Bian, Ting-Ting Tang*
Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
Abstract: Recent studies have demonstrated that mesenchymal stem cells (MSCs) had close relationship with various tumors. MSCs could be recruited by tumors， and co-injected exogenous MSCs or systemically injected exogenous MSCs involved in the formation of tumor stroma. MSCs had immunosuppressive properties and would promote tumor growth in vivo. The interaction between MSCs and tumor cells which mediated by soluble factors or direct cell contact could inhibit the apoptosis of tumor cells， enhance the proliferation of tumor cells and promote tumor metastasis. Cell-mediated anticancer gene strategies could be developed based upon the homing of MSCs to tumor site.
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