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Mechanism of Ephedrine Inhibiting Proliferation of Bronchial Smooth Muscle Cells
Hong-Juan Jing, Chang-Dong Wang, Lu Gan, Xu Yan, Peng Chen, Guang-Yuan He*
Key Laboratory of Molecular Physics, Ministry of Education, China-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Abstract: BK channel is a kind of big conductance， voltage and Ca2+-activated potassium channel which exists in almost all tissues in mammal. The β1 subunit was first detected as an ancillary subunit of BK channel in smooth muscle cells and had significant influence on the biophysical properties of BK channel. Mahuang， as a β-adrenergic receptor agonist， is a Chinese traditional medicine treated as asthma. In this paper， RT-PCR and patch clamp were used to approach the mechanism of Mahuang treated on asthma. The finding results showed: Ephedrine which was the most components of Mahuang suppressed the proliferation of bronchial smooth muscle cells (BSMCs) and restrained the expression of β1 subunit of BSMCs. But， ephedrine had little effect on the current amplitude of BK channel.
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