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MicroRNAs and Heart Diseases
Hui-Bin Liu, Ya-Qi Shen, Zhao-Hua Zhong*
Department of Microbiology, Harbin Medical University, Harbin 150081, China
Abstract: MicroRNAs are small non-coding RNA molecules encoded in the genomes of plants and animals. These highly conserved 21-25 mer RNAs regulate the expression of genes by binding to the 3' untranslated regions of specific mRNAs. MicroRNAs modulate the processes of embryonic development， cell proliferation， cell differentiation， cell death， and apoptosis by post-transcriptional regulation mechanism. Recently researches demonstrated that abnormal expressions of microRNAs may cause the initiation and progress of heart diseases. The role of microRNAs in heart development， myocardial remodeling， heart failure， and arrhythmia was reviewed
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