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Cell Adhesion Molecules in Tumor Development and Progression
Ya Chen, Ting lv, Jing-Jing Hu,Yan-Jie Wu, Ya-Jin Qiu, Wei Zhou, Jing-Wei Xu, Yan-Yun Zhang*
Shanghai Institute of Immunology, Institutes of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract: Cell adhesion molecules are some of cell surface molecules that mediate specifically adhesion between cell-cell and between cell-matrix. They play important roles in physiological and pathological procedures， such as maintaining tissue organization and directing the migration of leukocytes. Perturbances in cell adhesion molecule activity can disrupt normal cell-cell interactions and form abnormal interactions， which lead to tumorigenesis and metastasis. Therefore， further investigation of the role of cell adhesion molecules in tumors would provide a novel insight into the molecular mechanisms of tumor development and metastasis. It is also helpful for establishing new strategy to anti-tumors.
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