Nucleolar Proteins: Their Location， Translocation and Nucleolar Functions

Abstract: The nucleolus is traditionally known as a place for ribosome biogenesis. However， various unexpected roles for the nucleolus have been indicated by the research during the past decade. The nucleolus is a highly dynamic subnuclear compartment in which various nucleolar proteins are transported in and out accompanying with ribosome-related rRNA and proteins. While under stress conditions， nucleolus serve as the cell stress sensor. Many nucleolar proteins change their location and distribution in and out of nucleolus， and alter their functions， to mediate response to the stress.

CSTR: 32200.14.cjcb.2008.05.0005