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The Role of NBS1 in DNA Double Strand Break Damage Response and Telomere Stability
Hao-Hong Luo, Rui-Chuan Chen, Cheng Li*
The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Abstract: The NBS1 is a component of the MRE11/RAD50/NBS1 complex (MRN) and plays a critical role in the DNA double strand break (DSB) repair and the maintenance of chromosomal integrity. The telomere is a unique chromosomal structure consisting of repetitive DNA sequences bound by protein complexes， which is similar with DSB. The mechanisms of NBS1 in DNA damage response and maintenance of telomere stability are reviewed in this paper.
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