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Function of Ctk1 in Autophagy Process
Le Yan1, Zhou Lanjiang2, Yi Cong1*
1School of Life Science, Tsinghua University, Beijing 100084, China; 2School of Chemistry and Biology Engineering,Yichun University, Yichun 336000, China
Abstract: Autophagy is a lysosome dependent intracellular degradation process， which engulfs molecules or organelles in a double membrane structure to lysosome and then degrade. It was investigated that Ctk1 played an important role in autophagy. In Ctk1 loss yeast or Ctk1 activity deficiency yeast cell， autophagy was impaired and the CVT pathway was also inhibited. We then fould that the interaction between Atg3 and Atg8 was regulated by Ctk1. Therefore， Ctk1 contributed to the formation of autophagosome. Our work provided new information about the regulation of autophgy and the function of Ctk1.
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