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Histone Arginine Methylation and Early Development in Zebrafish
Zhao Xinxi, Li Yiping*
Shanghai Key Laboratory for Molecular Andrology, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Development is determined by spatial and temporal gene expression patterns， the epigenetic mechanisms of which has been paid more and more attention. Histone arginine methylation is post-translational modification (PTM) generated by protein arginine methyltransferases， and regulates the structure and function of chromosome. There are complicated cross talks between PTMs at different R sites and its adjacent sites， which lead to expression activation and repression by recruiting or blocking the relative effectors. Zebrafish is an important model in development study， and has contributed to the physiological roles of protein arginine methyltransferases. This review will summarize the generation of histone arginine methylation， its cross talk with other PTMs， and its physiological roles in early development of zebrafish.
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