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Research Progress on Notch Signaling Pathway and Germline Stem Cells
Li Jia1, Sun Mengli1, Huang Jian1, Pan Xiaoling2, Zheng Yuehui1*
1Department of Experimental Teaching, Nanchang University, Nanchang 310006, China; 2Periodical Press, Nanchang University, Nanchang 310006, China
Abstract: As a high evolutionarily conserved system during evolution， Notch signaling pathway participates in regulation of cellular differentiation， proliferation and death. In recent years， researches have shown that the element of Notch signaling pathway is complex， which is primarily related to proliferation and differentiation of germline stem cells and the role of stem cell niche. It also plays an extremely important role in reproductive system development and disease treatment. In this study， we summarized the physiological characteristics and functions of Notch signaling pathway， and focused on the role of regulating onfemale germline stem cells， male germline stem cells and germline stem cell niche.
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