Progresses and Perspectives on the Role of Tom1L1 in Signal Transduction and Endocytosis Pathways

Abstract: Tom1L1 (Tom1 like 1) participates in cell signal transduction pathways and receptors’ endocytosis. It has different effects on cell signal transduction depending on cell types. Moreover， Tom1L1-CHC (clathrin heavy chain) complex represses mitogenic and transforming signals by reducing the level of Src in caveolae. EGFR (epidermal growth factor receptor) stimulates transient tyrosine phosphorylation of Tom1L1 by the SFK (src family kinases)， and pTom1L1 (phosphorylated Tom1L1) promotes endocytosis of EGFR bridged by Grb2 and Shc. Tom1L1 also interacts with Hrs (hepatocyte growth factor regulated tyrosine kinase substrate) and TSG101 (tumor susceptibility gene 101)， which suggests that it might play a role in sorting of ubiquitinated proteins into MVB (multivesicular body). This review will focus on the specific role of Tom1L1 in signal transduction pathways and the endocytosis/sorting of receptors.

CSTR: 32200.14.cjcb.2014.06.0020