Home > Browse Issues > Vol.36 No.6
The Roles of MicroRNAs in CNS Development and Regeneration of Spinal Cord Injury
Zou Hongjun1, Gao Xin1, Zhang Jian1, Ding Ya1, Gong Aihua2, Liu Jingbo1*
1Department of Orthopedics, the Third Affiliated Hospital of Suzhou University, Changzhou 213003, China; 2School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China)
Abstract: MicroRNAs (miRNAs) are RNA molecules composed of 20~24 nucleotides which have key roles in normal CNS development and functions， as well as in diseases. miRNAs express in temporal and spatial patterns during the development and differentiation of CNS， and play key roles in maintaining biological memory and clock. Moreover， the abnormal expression of miRNAs may be related to pathological process of spinal cord injury. Emerging evidences suggest that miRNAs can not only maintain neural stem cell proliferation， but also promote neuron axon elongation. So， miRNAs can provide new treatment strategies for the spinal cord injury.
CN
EN