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Prdm1 Functions in Mammalian Embryonic and Germ Cell Development
Li Na, Wu Jiang, Hua Jinlian*
College of Veterinary Medicine, Shaanxi Stem Cell Engineering and Technology Research Center,Northwest A&F University, Yangling 712100, China
Abstract: Prdm1 (PR domain zinc finger protein 1)， also known as Blimp1 (B-lymphocyte-induced maturation protein-1)， is a transcriptional factor with a zinc-finger domain. It regulates the differentiation of multiple cell types by affecting the expression of relevant genes. Since reported in 1991， its function in regulating the terminal differentiation of B cells into plasma cells has been extensively studied. However， the function of Prdm1 in embryonic development of mice and other animals has not been well understood， specifically in germ cell development and differentiation. Recently， it has been demonstrated that Prdm1 had an important role in the formation of primordial germ cell (PGC)， the maintenance of stem cell characteristic， and the formation of multiple tissues and organs during embryo development.
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