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Research Update of Relationship between Notch Signaling Pathway and Cardiac Stem Cells
Jiang Xiaofan, Ding Ranran, Jiang Hanguo*, Jie Wei*
Department of Pathology, School of Basic Medicine Sciences, Guangdong Medical College, Zhanjiang 524023, China
Abstract: Notch signaling is a highly conserved signaling pathway in a wide variety of animal cells， which plays an important role in stem cells biology. Cardiac stem cells (CSCs) are multipotent cells which locate in the niche of heart. Notch receptors are distributed on the CSCs membrane and the neighboring cells express Notch ligand， suggesting Notch signaling in CSCs could be re-activated under certain conditions. In the present paper， we reviewed the composition and activation of the Notch signaling pathway， the definition and origin of CSCs， the general biological characteristics of the main types of CSCs and the relationship between Notch signaling pathway and the formation， differentiation and proliferation of CSCs， as well as the perspectives of CSCs in the myocardial regeneration by CSCs transplantation.
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