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Effects of Retinol (Vitamin A) on Biological Characterization of Mesenchymal Stem Cells from Human Umbilical Cord In Vitro
Liu Dan, Yu Shumin*, Liu Huanhuan, Song Pin, Cao Suizhong, Shen Liuhong, Zhang Kun, Zuo Zhicai, Deng Junliang, Ren Zhihua, Wang Ya, Ma Xiaoping
College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China
Abstract: This work was designed to investigate the effects of vitamin A on the proliferation of human umbilical cord mesenchymal stem cells (hUCMSCs). The results showed that after in vitro treatment of hUCMSCs with vitamin A， the biological characteristics of hUCMSCs could be performed. The expression patterns of hUCMSCs markers and stem cell markers， including CD29， CD44， Oct4， Sox2 and Nanog， were also detected. In addition，we confirmed that vitamin A could stimulate the proliferation of hUCMSCs. The transcriptions of biomolecules，such as PCNA， C-myc and Nanog， were significantly elevated， while the transcript of Bcl-x declined. It was identified that the vitamin A could trigger the characteristics maintenance and proliferation of hUCMSCs， which might be crucial to reveal the regulation mechanism of vitamin A on the proliferation of hUCMSCs.
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