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Extracellular Electrical Fields Direct Cell Behaviors in Tissue Repair
Liu Yongling1, Gao Runchi1, Zhao Sanjun1, Zhao Min1,2, Wang Xiaoyan1*
1Regeneration Biology Research Section,Yunnan Normal University, Kunming 650500, China; 2School of Medicine, University of California at Davis, California 95616, USA
Abstract: Tissue repair is a complicated process， which requires a complex interplay of diverse physiological， immunological and cell biological process. It has long been known that the endogenous electric fields exist at fresh wounds. Mimic experiments have shown that electric fields play a direction guidance in cell migration， polarization， proliferation and differentiation in wound healing. In this paper， we reviewed the advance of extracellular electrical fields guid cell migration， polarization and proliferation in wound healing， bone healing and revascularization， which might be a potential way in tissue repair.
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