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The Role of Mitofilin in the Regulation of Mitochondrial Functions and Its Implication in Diseases
Kuang Linyun, Dong Shiye, Liu Danhui*
School of Laboratory Medicine, and Life Sciences, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou 325035, China
Abstract: Mitofilin， a mitochondrial inner membrane protein， is involved in many important biological processes such as the maintenance of mitochondrial cristae morphology， mitochondrial protein transport processes， etc. Alteration of mitofilin expression level does not only affect mitochondrial structure， but also significantly inhibits normal mitochondrial functions. Recent studies showed that mitofilin was abnormal expressed in a variety of diseases， leading to altered mitochondrial structural integrity and functions， and promoting the development of the diseases.
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