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The Role of TFIID in Gametogenesis and Early Embryonic Development
Hao Guoli, Yu Haiquan*
The Key Laboratory of Mammal Reproductive Biology and Biotechnology, Ministry of Education,Inner Mongolia University, Hohhot 010070, China
Abstract: Gametogenesis and early embryonic development are regulated by precise and well-ordered gene expression. A variety of transcription factors bind to target genes to activate their expression in a spatially and temporally specific manner during these processes， which controls the acquisition of zygotic totipotency， the maternal to zygotic transition， and the regulation of embryonic cell differentiation. Previous studies have shown that trans-cription factor TFIID plays important roles in these development stages. Before the initiation of gene transcription， subunits of TFIID are recruited to target gene promoters， and form pre-initiation complexes with other transcription factors to initiate transcription. This review summarizes the structure and action mechanism of TFIID， as well as its regulatory roles in gametogenesis and early embryonic development.
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