Home > Browse Issues > Vol.30 No.4
Progress in Mitophagy
Dan-Hui Liu, Jian-Xin Lu*
Institute of Cellular and Molecular Medicine, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou 325035, China
Abstract: As reactive oxygen species (ROS) is a by-product of mitochondrial metabolism and mitochondrial DNA is more susceptible to oxidative damage than nuclear DNA， mitochondria are especially more prone to be damaged than other organelles. Timely elimination of aged and damaged mitochondria is essential to maintain the health of cells. The unhealthy mitochondria are mainly cleared by autophagy. Increasing evidence indicates that this is a selectively process termed mitophagy. The mitochondrial permeability transition pore plays important role in mitophagy. Mitophagy may play an essential role in maintaining mitochondrial function and genetic integrity， but its mechanism needs further investigation.
CN
EN