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Advances in the Research of Mammalian Spermatogonial Stem Cells
Sachula Wu1, Gu Tingyu2*, He Zhiying3, Muren Herrid4, Wang Xin1,2, Uyunbilig Borjigin1*
1The Key Laboratory of Mammalian Reproductive Biology and Biotechnology, Ministry of Education,Inner Mongolia University, Hohhot 010021, China; 2The laboratory of Cellular and Molecular Biology,Shanghai Institute of Cell Biology and
Abstract: Spermatogonial stem cells (SSCs) are the adult stem cells that are capable of self-renewal and differentiation into sperm cells in the male body. SSCs can maintain capacity of spermatogenesis throughout life in males， thus transmit genetic information to next generation though sperm cells. Under in vitro culture conditions，SSCs could be induced into several cell types including hematopoietic cells， neurons and muscle cells besides various cells relative to spermatogenesis. As the cell model， SSCs become an important tool for the researches on spermatogenesis mechanism， regeneration of spermatogenesis in sterile individuals and reproduction of transgenic animals. This article reviewed recent advances in the studies including biological properties， purification， culture，transplantation， induced differentiations and molecular regulation underlining these differentiations of SSCs.
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