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Regulatory Effects of Tumor Suppressor CYLD on Cell Function
Zhang Cheng1,2, Wang Ping1, Du Yantao1, Duan Shiwei1*, Ye Meng2*
1Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China; 2Department of Medical Oncology, the Affiliated Hospital, School of Medicine, Ningbo University, Ningbo 315000, Chin
Abstract: Tumor suppressor CYLD is a deubiquitination enzyme， which contains a deubiquitinase domain and three cytoskeleton-associated protein glycine-rich domains. The deubiquitinase domain can regulate signal transduction pathways by deubiquitinating signal molecules. The CAP-Gly domains mediate multimerization and acetylation through regulating microtubule chiefly， in turns changing its assembly and permutation. CYLD regulates cell proliferation， apoptosis， cell movement and cell differentiation through the adjustment of signal transduction and cytoskeleton. In this review， recent progress in studying the regulatory effects of tumor suppressor CYLD on cell function was summarized.
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