Home > Browse Issues > Vol.36 No.1
Association between NLRP3 Gene Polymorphism and Colorectal Cancer from Chinese Han Population
Ren Xiaojun*, Zhao Ming, Duan Feng, Wang Xiaofeng, Zhang Yan, Song Zhewei
Department of Surgery, Wujing Hospital of Minhang District of Shanghai, Shanghai 200241, China
Abstract: The aim was to evaluate the relationship between NLRP3 gene and colorectal cancer (CRC). The sample set consists of 208 CRC patients and 203 controls. 3 SNPs (rs4925648， rs10754558， rs10925019) of NLRP3 gene were tested using Taqman technology. The allele frequency， genotypic frequency and haplotype were analyzed between case group and control group. There were no significant difference of allele frequency and genotypic frequency between these two groups (P>0.05). The D’ value of rs4925648 and rs10925019 was large (D’=0.798). The haplotype of these two SNPs was negative. In conclusion， there was no significant association between rs4925648，rs10754558， rs10925019 and CRC from Chinese Han population.
CN
EN