Home > Browse Issues > Vol.35 No.11
Research Advances in Protein O-GlcNAcylation
Xu Lin, Yu Hongjiao, Guan Dong, Yin Yibo, Liang Hongsheng, Zhang Xiangtong*
The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Abstract: The O-GlcNAc modification of protein is one of the essential post-translational modifications in the body， which modification mode is similar to the phosphorylation， and they interact with each other and work cooperatively to regulate the activity of biomacromolecules. The O-GlcNAc modification plays an important role in the process of transcription， translation， nucleus transport， cytoskeletal formation and regulating the functions of organelles. Through its effects on the intracellular signal transduction pathways， it is also involved in the processes of phagocytosis， inflammatory cell migration and intracellular macromolecules circulation. In this article， we briefly explained the role of O-GlcNAcylation in the organism mainly through introducing the basic theory of protein O-GlcNAcylation and several aspects of its functions.
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