Home > Browse Issues > Vol.35 No.11
Expansion of Mesenchymal Stem Cells by Microenvironmental Simulation
Lou Xiangxin, Yuan Huihua, Bao Min, Zhang Yanzhong*
Laboratory of Biomimetic Biomaterial for Regenerative Medicine, Department of Bioengineering, College of Chemistry,Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
Abstract: Nowadays， mesenchymal stem cells (MSCs) have been most commonly utilized in a variety of cell therapies and tissue regenerations. But how to achieve efficient expansion of MSCs with retained stemness for clinical application remains a ‘bottleneck’ problem to be addressed in the basic research and clinical treatment. A growing number of studies have shown that the self-renewal and differentiation of MSCs could be precisely regulated by their microenvironment in vivo， so precise simulation of the in vivo microenvironment has become a rational strategy for MSCs expansion. This review aims to summarize the recent advances on simulating stem cell growth microenvironment to induce MSCs amplification with preserved stemness characteristics in vitro. A comprehensive understanding of this field may provide guidance for efficient expansion of MSCs to accelerate the application and transformation of the MSCs in the clinical settings.
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