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Relationship of Dendritic Cells and Tumor Immunity
Wang Bing1#, Wang Hongmei1#, Xu Fangyun1, Min Weiping2,3*
1Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China; 2Medical College of Nanchang University, Nanchang 330006, China; 3Jiangxi Academy of Medical Sciences, Nanchang 330006, China
Abstract: Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) which have the dual capacities in regulating immune response and immune tolerance depending on their maturation and surface markers. The function of DCs is associated with its maturation degree. Immature DCs mediate immune tolerance while the matured DCs play a critical role in tumor immunity. We will summarize DCs′ heterogeneity and the relationship between DCs and tumor immunity in this review.
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