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Somatic Variations of Mitochondrial DNA in Carcinogenesis and Tumor Progression
Wang Peng, Jiao Jianhua, Li Deyang, Huang Qichao, Xing Jinliang*
Cadet Brigade of Fourth Military Medical University, Xi’an 710032, China; Preclinical Medical Teaching Experiment Center of Fourth Military Medical University, Xi’an 710032, China
Abstract: Mitochondria is one of intracellular organelles responsible for generating ATP through respiration and oxidative phosphorylation， producing reactive oxygen species， and initiating and executing apoptosis. In recent years， there is increasing evidence that somatic mitochondrial DNA (mtDNA) variations are associated with various cancers， and these may be involved in carcinogenesis and tumor progression. Therefore， understanding mtDNA variations in cancer cells promises to provide major new insights into the etiology of solid tumors and be of great potential benefit for prognosis and possible treatment of cancer.
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