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Effect of Quercetin on the Expression of TGF-β1， TNF in Alveolar Macrophage
Peng Haibing1*, Wang Jianxing1, Liu Yan2, Tian Jiali1, Wang Xianhua2, Qin Lijuan2, Mu Yu1
1Jitang College, Hebei United University, Tangshan 063300, China;2College of Basic Medical Sciences, Hebei United University,Tangshan 063000, China
Abstract: The silicotic alveolar macrophages were collected by bronchoalveolar lavage and were incubated in vitro. Alveolar macrophages were allocated into a blank group， a silicotic group and groups containing quercetin 10， 20， 40 μmol/L， respectively. Alveolar Macrophages were incubated for 2， 6， 12， 18， 24， 36 h. The expression levels of TGF-β1 and TNF in alveolar macrophage and P-p38MAPK in supernatant were analyzed. We found that the expression level of TGF-β1， TNF and P-p38MAPK were significantly (P<0.05) higher in silicotic groups than the blank groups in the same period. After treated with different concentration of quercetins， the expression levels of TGF-β1， TNF and P-p38MAPK were lower. The greater the concentration of quercetin， the less they were detected.We speculate that quercetin could down-regulate TGF-β1 and TNF expressions in AM upon silicotic exposure by regulating p38 MAPK signal transduction pathway.
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