Home > Browse Issues > Vol.35 No.9
Advances in Studies on Autologous PBSCT for Treating Diabetic Foot
Li Xiaolin1,2, Gao Huailin2,3* Pang Jie4,5
1 Hebei Meidical University, Shijiazhuang 050017, China; 2 Yiling Hospital of Hebei Medical University, Key Laboratory of Preventionand Treatment of Diabetic Foot Under the Guide of Collateral Disease Theory, Shijiazhuang 050091, Chi
Abstract: In recent years， the prevalence of diabetes shows a rapid growth in the world. In 2008， an epidemiological survey showed that the prevalence of Chinese urban population diabetes was 11%. For patients and society diabetes has become a huge burden. With the development of molecular biology， molecular immunology and cell biology， the stem cells transplantation gradually becomes an important treatment for diabetes and diabetes complications. With a high morbidity， diabetic foot is one of the chronic complications of diabetes， and is a great threat to health and reduces the quality of life. The traditional drugs， surgery， interventional procedures， and amputation treatment all have limitations. As a new method， stem cell transplantation has emerged， which rapidly developed and been used in clinical treatments. The theory behind this is the differentiation potential of stem cells，which can differentiate into a variety of body cells， including vascular cells and endothelial progenitor cells， and further stem cells can form new capillaries. By this principle， autologous stem cell transplantation was used in the treatment for diabetic foot， the stem cells were transplanted into the ischemic foot. In one hand it can improve the regional blood flow， in the other hand， it has no short-term adverse reaction.
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