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Current Research Advances in Relationship between S100P and Digestive Cancer
Lin Feiyan, Jiang Lei*
Laboratory of Internal Medicine, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China
Abstract: S100P is a small calcium-binding protein that belongs to S100 protein family. It functions as extracellular and/or intracellular regulators of diverse cellular processes and participates in various human pathologies. S100P expression was detected in many different cancers， and its expression is associated with tumor growth， metastasis， drug resistant and poor clinical outcome. This review focuses on the functions and mechanisms of S100P， and the S100P protein may serve as a potential biomarker and therapy target in digestive system cancer.
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