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The Effects of c-kit on Development of Male Germ Cells in the Mammal’s Testis
Sachula, Kong Qunfang, Wu Yingji*
Key Laboratory of China Education Ministry for the Research of Mammal Reproductive Biology and Biotechnology,Inner Mongolia University, Hohhot 010021, China
Abstract: The roles and characteristics of c-kit/SCF signaling pathway have been widely reported. But there is not enough research available about mammalian c-kit detailed structure， functions， expression and transgenic models. Further the difference of researching pattern caused some unclear results and remaining debates.Here， we described the structure and functions of mammal’s c-kit gene， then emphasized its expressional pattern and roles in germ cell development of transgenic models and domestic animals. Finally， we discussed in depth about its potential roles in male germ cells proliferation， differentiation and fertilization. By introducing systematically about c-kit， its important functions in spermatogenesis have been defined， which might be a reference for future research about proliferation， differentiation and immigration in male germ cell.
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