Home > Browse Issues > Vol.35 No.4
Generation and Phenotype Analyses of TRPV2 Conditional Knockout Mice
Wang Yaoli1, Zhang Mengjie1*, Wolfgang Schwarz3, Cai Lei2, Kuang Ying2, Fei Jian1,2
1School of Life Science and Technology, Tongji University, Shanghai 200092, China;
2Shanghai Research Center for Model Organisms, Shanghai 201203, China;
3Shanghai Research Center for Acupuncture & Meridian, Shanghai
2Shanghai Research Center for Model Organisms, Shanghai 201203, China;
3Shanghai Research Center for Acupuncture & Meridian, Shanghai
Abstract: TRPV2， one member of the TRP cationic channels family， mostly distributes in myelinated Aδneurons and C fiber neurons. It was considered to play an important role in the mechanical and noxious heat sensation.TRPV2 was also detected in many non-neuronal tissues which maintained the ionic equilibrium of principal Ca2+ and Mg2+and indicated its various functions in vivo. For further TRPV2 functional studies， TRPV2 conditional knockout mouse strain was constructed by using Cre-loxP method in our lab. Several basic phenotype analyses were conducted in the TRPV2 knockout mice. The results showed there were no differences in the bodyweight，blood pressure， study， memory and motor coordination between TRPV2 knockout mice and WT mice while the birth rate was lower in KO mice.
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