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Mechanisms on Immunogenicity of Induced Pluripotent Stem Cells and Interferring Strategies
WangYajie, Hao Sha, Yuan Weiping, Cheng Tao*
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
Abstract: Induced pluripotent stem cells (iPSC) hold the great promise for dealing with a wide range of genetic and acquired diseases in regenerative medicine. However， to reveal the full potential of iPSC， many obstacles must be overcome. Immunogenicity of iPSC appears to be an important and controversial issue surrounding potential therapeutic applications of iPSC. In the current review， we discuss the mechanisms that contribute to the immunogenicity of iPSC and iPSC-derived cells， and highlight the potential strategies for successful engraftment of iPSC-derived cells in the recipients.
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