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The Signal Pathways Involved in Regulating the Expression of Fibronectin
Li Yanan, Li Jingbao, Shang Peng, Qian Airong*
Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Institute of Special Environmental Biophysics,Northwestern Polytechnical University, Xi’an 710072, China
Abstract: Fibronectin (Fn)， as one of the most important adhesion molecules of extracellular matrix (ECM)，
regulates a series of cellular processes， including adhesion， migration and proliferation， by binding to the intergrin
receptor on the cell membrane. The abnormal expression of Fn is closely related to wound healing， tumor metastasis，
tissue and organ fibrosis. Many signaling pathways can regulate Fn expression， such as MAPK， TGF-β1/Smad，
PKC， JAK/STAT and JNK/NF-κB/NADPH/ROS. Here， we review several signal pathways of regulating Fn expression，
which will be helpful to comprehensively understand the mechanism of Fn’s involvement in the organism’s
adaptation to diverse environments and related diseases.
regulates a series of cellular processes， including adhesion， migration and proliferation， by binding to the intergrin
receptor on the cell membrane. The abnormal expression of Fn is closely related to wound healing， tumor metastasis，
tissue and organ fibrosis. Many signaling pathways can regulate Fn expression， such as MAPK， TGF-β1/Smad，
PKC， JAK/STAT and JNK/NF-κB/NADPH/ROS. Here， we review several signal pathways of regulating Fn expression，
which will be helpful to comprehensively understand the mechanism of Fn’s involvement in the organism’s
adaptation to diverse environments and related diseases.
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