Home > Browse Issues > Vol.34 No.10
Regulatory Effects of HIF-1 on the Angiogenesis during Ovarian Luteal Development
Wu Yanqing1, Zhang Zhenghong1,2, Luo Qianping1, Chen Liyun1, Wang Zhengchao1*
1Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China; 2Provincial Research Center for Animal Transgenesis and Biopharming, College of Veterin
Abstract: In mammals， ovarian corpus luteum is formed from the ruptured follicle after ovulation， where the angiogenesis is much more intense. Especially in the early developmental stage of the corpus luteum， this rapid formation of a dense capillary network can ensure the cells， which produce hormones， to obtain oxygen， nutrients and the necessary precursors of synthetic hormones. At the same time， it can release a large number of hormones for establishing and maintaining early pregnancy. The current investigations have shown that vascular endothelial growth factor (VEGF)， as an important angiogenic factor， plays a crucial regulatory role in angiogenesis during the development of corpus luteum， while as a downstream target gene of the transcription factor HIF-1 (hypoxia-inducible factor-1)， VEGF is regulated by HIF-1 signaling pathway. In the present paper， we firstly overviewed the regulatory mechanism of VEGF-dependent angiogenesis during the development of corpus luteum， and then described the regulation mechanism of transcription factor HIF-1 on the transcriptional activation of VEGF. All of these will reveal the regulatory role of HIF-1 in VEGF-dependent angiogenesis during the development of corpus luteum， which can provide a solid theoretical foundation for further studying the molecular mechanism of the angiogenic regulation during the development of corpus luteum in mammalian ovary.
CN
EN