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Signaling Pathways of mTORC2 Regulate Actin Cytoskeleton
Chen Yintao1, Yu Bingzhi2, Wu Didi2*
1School of Clinical Medicine, China Medical University, Shenyang 110001, China; 2Department of Biochemical and Molecular Biology, China Medical University, Shenyang 110001, China
Abstract: Researches about the role of the target of rapamycin complex 2 (mTORC2) during various mammalian cells have always been progressing， a process that is mediated through the polarization of actin and myosin filament networks. The concrete routes of upstream and downstream regulatory molecules of mTORC2 are still undetermined. Based on large experiment data upon the filed from recent years， we can roughly conclude four routes by which mTORC2 regulate actin cytoskeleton to fulfill motility， adhesion， fission and some other biological functions. Some important proteins or molecules associated with the process have been found successively. They are P-Rex1/2， Rho family GTPase， PKC， cAMP， p27Kip1 and so on. This review will try to draw roughly the routes map with the related proteins or molecules that have been known. But all remain to be identified by more evidences and experiments.
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