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Advances in the Research of Mitophagy
Liu Lei1, Feng Du2, Zhu Yushan2, Chen Quan1,2*
1Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; 2College of Life Sciences, Nankai University,Tianjin 300071, China
Abstract: Selective degradation of damaged or dysfunctional mitochondria by autophagy is defined as mitophagy. Mitophagy plays an essential role in maintaining mitochondrial integrity and the survival of cells. Although deregulation of mitophagy is associated with many human diseases， the precise mechanisms of mitophagy still remain elusive. This review focuses on the most recent advances related to mechanisms and physical relevance of mitophagy.
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