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Research Advances in Autophagy Protein NDP52 and Bacterial Infection
Wang Fenfen, Zhang Jixiang*
Digestive Department, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
Abstract: Autophagy is an important pathway to eliminate intracellular bacteria in mammals and defend the host cell from bacteria damage. In addition to p62/SQSTM1 and NBR1， NDP52 (nuclear dot protein 52)—one of the members of nuclear dots， is a novel autophagy related protein has been found. NDP52 is an adaptor protein that binds to both ubiquitinated bacteria (such as Salmonella and Streptococcus pyogenes) and LC3 (microtubule associated protein 1 light chain 3)， and then delivers these invaders into autophagosomes. This finding helps further understand the specific molecular mechanism of autophagy resisting pathogens infection， and provides a new target for the prevention and treatment of bacteria infection.
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