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Detection of Circulating Tumor Cells Using MicroRNA as A Novel Marker and Its Clinical Significance
Zheng Yuanyuan, Xiao Bingxiu, Le Yanping, Guo Junming*
Department of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China
Abstract: Circulating tumor cells (CTCs) are solid tumor cells that circulate with blood stream. They are closely associated with the cancer， progress， metastasis， relapse and prognosis. However， the limited number of CTCs makes their efficient detection a big challenge. MicroRNAs (miRNAs)， the newly found gene expression regulators， play important roles in cancer recurrence， progress and outcome. The studies on the CTC-associated miRNAs open us mind about CTC detection， and cancer diagnosis and treatment. In this paper， we first introduced the clinical significance of CTCs and the main detection methods， and then summarized the recent research progresses of the relationships between CTC-associated miRNAs， which have been considered as novel tumor cell markers， and cancer diagnosis， treatment and outcome.
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