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MicroRNA and Drug Resistance in Lung Cancer
Dong Zhuo, Yang Lihua, Zhong Zhiwei, Gong Zhaohui*
School of Medicine, Ningbo University, Ningbo 315211, China
Abstract: Drug resistance induced by chemotherapeutants to lung cancer cells is the primary issue during the chemotherapy of lung cancer. MicroRNAs (miRNAs) are a class of endogenetic， non-coding， short-chain and small RNAs that regulate cell growth， apoptosis and signaling transduction. miRNA polymorphisms associte with drug metabolsim and drug resistance formation. Moreover， differentially expressed miRNAs play critical roles in prediction of the sensitivity to chemotherapeutic agents in lung cancer. Regulation of specific miRNA expression will break a new path for overcoming lung cancer resistance and the personalized therapy.
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