Molecular Cell Mechanism of Autophagy

Abstract: Autophagy， a highly conserved mechanism in eukaryotes， is a lysosome-dependent pathway for the turnover and recycling of intracellular macromoleculars and damaged organelles. Autophagy is involved in multiple physiological and pathological processes. Autophagy-related study is becoming a worldwide hot-spot of life science. Clarification of the molecular and cellular mechanism of autophagy， and the significance of autophagy in the physiological/pathological processes， will contribute in a great degree to the prevention and therapy of the diseases. This review aims to summarize the recent achievements in autophagy field by focusing on the induction of autophagy and its role in related diseases.

CSTR: 32200.14.cjcb.2012.04.0011