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The Research Progress of Neural Stem Cell Transplantation


Qian Xiaodan, Luo Chunxia, Zhu Dongya*
Lab of Cerebrovascular Diseases, School of Pharmacy, Nanjing Medical University, Nanjing 210029, China
Abstract: Neural stem cells (NSCs) are the self-renewing, multi-potent cells that generate the main phenotypes of the nervous system, including neurons, astrocytes, oligodendrocytes and so on. The intrinsic neurogenesis of adult mammals is limited and can not compensate for the neuronal loss caused by nervous diseases. So, the researchers are exploring the novel treatments for central nervous diseases by exogenous neural stem cells transplantation. Up to now, many animal studies have been performed in this field, and several transplantation techniques are developed. The review focuses on the properties and original sources of NSCs, the means of engraftment, and the recent progress of research in NSCs transplantation.


CSTR: 32200.14.cjcb.2012.03.0002