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The Progress of Mechanism Study on Pathogenic Microorganism Survival by Manipulation of Innate Immune Cells
Zhang Ling1, Liang Wenzhang1, Chen Min2, Ma Cuiqing1*
1Department of Immunology, Hebei Medical University, Shijiazhuang 050017, China;2Huabei Petroleum Center for Disease Control and Prevention, Renqiu 062552, China
Abstract: The innate immune mechanisms are utilized by host to prevent a range of bacteria in acute and conserved infectious pattern. However， successful intracellular pathogens can evade， inhibit or subvert immune detection， signalling transduction or effective damages. In this review， we focus on how bacterial pathogens manipulate host-cell defence system and regulate intracellular killing or signaling， and how to disrupt the molecular signaling crosstalk between receptors of the innate immune system， eventually contibuting to bacterial adaptive fitness and persistent infections in the host.
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