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Advance in Research on Contact Inhibition of Locomotion
Deng Lulin, Zhang Jixiang*
The Second Affiliated Hospital of Nanchang University, the Key Laboratory of Molecular Medicine, Nanchang 330006, China
Abstract: The migration of cells generally exists in a variety of pathological and physiological process， such as embryonic development， wound healing， immune response and tumor metastasis. Contact inhibition has been regarded as one of the mechanisms related to the migration of cells， and it performs that when the cells contact with others in its migration， they will retract their protrusions and change the direction of motion. Furthermore， the loss or weakening of contact inhibition is an essential step for tumor metastasis. This review will focus on how contact inhibition of location occurs and its molecular mechanism.
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