Home > Browse Issues > Vol.33 No.11
Immunostimulating Mechanisms of Polysaccharides on Macrophages
Yi Yang1,2, Cao Yin3, Zhang Mingwei1∗
1Bio-technological Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China;2College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China;3Zhixing College, Hu
Abstract: As widely distributed natural macromolecules， polysaccharides exhibit a number of biologic activities， especially immunopromoting effects on immune system. Bioactive polysaccharides can stimulate multiple signaling pathways via macrophage receptors followed by improving the secretion of cytokines， and finally enhance the cellular immune function. The present review focuses on the immunostimulating effects， potential mechanisms and structure-receptor relationship of polysaccharides on macrophages， which purposes to provide the basic information of polysaccharide-induced macrophage activation for related researches.
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