Home > Browse Issues > Vol.33 No.11
Age-related Study on Mice Bone Marrow Stem Cell and Peripheral Blood Composition as well as Their Correlation
Zhao Kai1, Yang Xingyu1, Wan Yinghan2, Sun Ruilin2*, Fei Jian1,2
1School of Life Science and Technology, Tongji University, Shanghai 200092, China;2Shanghai Research Center for Model Organisms, Shanghai 201203, China
Abstract: Peripheral blood cells are known to be derived from a self renewing population of hematopoietic stem cells residing in the bone marrow， but the relation between hematopoietic stem cells and the cells of peripheral blood is rarely understood. We explore the changes of CD34-/Sca-1+ hematopoietic stem cell population in bone marrow and peripheral blood composition of C57BL/6J mouse during aging. The CD34-/Sca-1+ cell population in bone marrow is increasing during the aging. We also study on the tendency of different cell lineages in peripheral blood and compare the tendency with that of bone marrow cells. The tendency of blood platelet density in peripheral blood shows high correlation with the percentage current of CD34-/Sca-1+ bone marrow hematopoietic stem cells. The tendency of lymphocyte density in peripheral blood shows extreme correlation with the percentage current of CD34+/Sca-1- bone marrow cells. The tendency of white blood cell density in peripheral blood shows high correlation with the percentage current of CD34+/Sca-1+ bone marrow cells.
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