Home > Browse Issues > Vol.33 No.8
Advances in Reprogramming of Peripheral Blood Cells to Induced Pluripotent Stem Cells
Li Shishi1,2, Liu Zhong3, Yan Qingfeng1,2*
1College of Life Sciences, Zhejiang University, Hangzhou 310058, China; 2Institute of Genetics, Zhejiang University, Hangzhou 310058, China; 3The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangz
Abstract: Induced pluripotent stem cells (iPSCs) are a type of embryonic stem cell-like cells which derived from adult cells by ectopic expression of a few defined transcription factors. The establishment of patientspecific iPSCs is very important for regenerative medicine and pathological mechanism study. Until now， the most common donor cells of human iPSCs has been from skin fibroblasts， which requires an invasive skin biopsy and a prolonged period of expansion in cell culture prior to use. These limitations prevent iPSCs technology broadly applicable. While the generation of human iPSCs from peripheral blood cells， which represents a fast， safe and efficient way of reprogramming will accelerate the development of iPSCs research. In this review， based on introducing different reprogramming methods， we focused on recent advances in iPSCs derived from mouse B cells， T cells to human cord blood cells and peripheral blood cells， and analyzed features and limits of this new iPSCs technology. The prospects of iPSCs research are also discussed.
CN
EN