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Research Progress on Leptin-mediated JAK/STAT Signaling Pathway in Lipid Metabolism
Wen-Zheng Wang, Su-Mei Zhao, Shi-Zheng Gao*
Yunnan Key Laboratory of Animal Nutrition and Feed Science, Yunnan Agricultural University, Kunming 650201, China
Abstract: Leptin-mediated JAK/STAT signaling pathway mainly involves in the regulation of lipid metabolism. Activated JAK/STAT signaling pathway increases the CPT-1 expression levels， involves in the regulation of lipid metabolism by promoting the synthesis of fatty acids. This article mainly focused on the latest research progress on component， mechanism and regulation of the Leptin-mediated JAK/STAT signaling pathway， the activation of some signaling pathways， such as JAK/STAT， PI3K/Akt and MAPK， induced by the combination of Leptin and its receptors， and the lipid metabolism regulation by these signaling pathways.
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