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Progress in the Regulation of Transcription Factor CREB on Cell Cycle
Cheng Zhang, Ping Wang*
Medical School, Ningbo University, Ningbo 315211, China
Abstract: Cell cycle is a complex and precise adjustment process， which involves numerous proteins. Endogenous molecules， cyclin、CDK and CKI， coordinate with each other and form a complexly regulatory network in the process of cell cycle regulation and cell signaling pathways. CREB (cAMP response element binding protein)， a transcriptional regulation factor in eucaryotic cell， regulates the cell cycle through changing the transcription of cyclin， CDK and CKI by its phosphorylation. In this review， recent progress in studying the regulatory effects of transcription factor CREB on cell cycle was summarized.
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