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Molecular Network of STAT3 During Embryo Implantation
Xiu Xu1, Zeng-Ming Yang2*
1College of Life Science, Northeast Agricultural University, Harbin 150030, China;2College of Life Science, Xiamen University, Xiamen 361005, China
Abstract: Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor. The inhibition of STAT3 activity in mouse uterus results in reduced implantation， suggesting that STAT3 plays an important role during embryo implantation. LIF and IL-11 are well-known implantation-related cytokines and can activate STAT3. Recent evidences show that STAT3 can also be activated by HB-EGF， VEGF and prostaglandin， which play profound roles during embryo implantation. Many important genes during embryo implantation， such as HIF1-α， COX-2 and p53， can be regulated by STAT3. miR-21 is also a downstream gene of STAT3. The interactions between STAT3 and the implantation-related genes form a complicated network， which may be critical for embryo implantation.
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